The bottom line is simply that hgh given by injection is the only form that works. The hgh sprays, hgh and supplements have not been proven to increase IGF1 levels.

Natural levels of hGH and IGF-1 decline progressively after young adulthood, leading to many of the bodily changes associated with aging. Raising hGH and IGF-1 levels to those associated with younger physiology slows down or delays the age related decline frequently seen in many organs.

What About Secretagogues or hGH Precursors?

What are acceptable methods of raising hGh/IGF-1 levels?

There are many companies that promote various pills, elixirs, sprays, or creams that are claimed to contain useful amounts of hGH; they claim that these products are actually taken up by the body through topical, oral, sublingual or nasal administration. One should be skeptical of such claims, as none of the published benefits of injected hGH have been objectively measured with oral tablets, capsules, or sprays.

It is important to understand that hGH is a very large polypeptide hormone--191 amino acids in exact sequence, maintained in a required three-dimensional shape. The only sources of safe and accurately assembled hGH are those that use recombinant DNA technology that requires elaborate, precise, and monitored methods. HGH, from any other source, even from other animals, simply does not work in humans. Similar animal molecules have been shown to be species-specific and unable to mimic the effect of the human molecule; and there is absolutely no naturally occurring plant source of hGH. The Food and Drug Administration (FDA) licenses and oversees companies that manufacture hGH. They must register and verify their methods and product regarding uniformity of quality, bioavailability, safety, and demonstrated effectiveness. This large protein molecule is unable to penetrate intact membranes to any significant degree, making any spray or oral use of hGH almost completely a waste. The technology to make hGH is patented by large pharmaceutical companies and is restricted by law to their use. It is an expensive manufacturing process, making waste prohibitively expensive. HGH may only be administered via injection by prescription under the supervision of a licensed physician through a licensed clinic or pharmacy.

Given the above requirements, there are several concerns that arise regarding the claims made by non-FDA approved companies that offer hGH products in oral or spray forms: